Gene fusion detection in solid tumours by anchored multiplex PCR (Archer FUSIONPlex pan solid V2 assay)

Test Code:

HT0213

Synonym(s):

Specimen Container

Specimen Requirement

10 unstained sections of tumour and a corresponding H&E-stained histological section, OR

1 paraffin block of tumour

Specimen Storage / Transport

Method

Orderable as STAT?

Turn Around Time

The test is batched and performed every Monday. The test itself takes 5 working days to complete.

Reference Value(s)

Testing Laboratory Location

KKH

Laboratory

Molecular Pathology

Contact Number

6394 1402

Day and Time Performed

Mon – Fri: 0800 hrs– 1700 hrs

Orderable on CPOE?

Downtime Form

Molecular Pathology

Additional Information

Background:

A proportion of solid tumours including sarcomas have gene fusions. Identification of specific gene fusions are important for diagnosis and may provide prognostic and predictive information.

Purpose of test:

This test identifies the presence of a gene fusion involving any of the 129 listed genes known to be involved in gene fusions in solid tumours of various histological subtypes by next-generation sequencing-based anchored multiplex PCR (Archer FusionPlex). Prior knowledge of the fusion breakpoints and partner genes is not required, and the breakpoints and partner genes are idenotified through their sequences. Refer to test request form for gene list.

Caveats:

RNA integrity and concentration must meet assay requirements. Low tumour content (<50%) may result in an inaccurate result.

Proficiency testing:

College of American Pathologists proficiency testing programme.

Change History Notes

Others

Keywords

Gene fusion detection in solid tumours by anchored multiplex PCR (Archer FusionPlex pan-solid assay) HT0213

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